von Hippel-Lindau disease
MeSH: D006623ORPHA: 8921 Treatment Available
Overview
a rare genetic disorder characterized by visceral cysts and benign tumors in multiple organ systems with potential for subsequent malignant change.
Available Treatments (1)
| Drug | Form | Status | Countries | Lead Time |
|---|---|---|---|---|
| Belzutifan Orphan | Oral tablet, 40mg | FDA Approved | 5 | 14d |
Clinical Presentation
Signs and symptoms associated with von Hippel-Lindau disease, sourced from HPO and Orphanet clinical annotations.
Abnormality of the eyeHypertensionRenal cell carcinomaAdrenal pheochromocytomaCerebellar hemangioblastomaRetinal capillary hemangiomaElevated urinary catecholamine levelVisual lossAnxietyHyperhidrosisPallorPapilledemaHypertensive retinopathyStrokeCardiomyopathyPancreatic cystsPalpitationsAbdominal painHeadacheVertigoElevated circulating catecholamine levelBack painUpper limb muscle weaknessAbnormal left ventricular functionMultiple renal cystsPancreatic islet cell adenomaDistal lower limb muscle weaknessPapillary cystadenoma of the epididymisLimb painArrhythmiaEndolymphatic sac tumorPancreatic endocrine tumorMacular edemaRetinal detachmentMyocardial infarctionPolycythemiaIncreased intracranial pressureParagangliomaNeoplasm of the pancreasMyocarditisEpididymal cyst
Classification & Codes
MeSH Code
D006623Orphanet Code
ORPHA:892von Hippel-Lindau disease
| MeSH | D006623 |
| Orphanet | ORPHA:892 |
| Treatments | 1 drug(s) |
| Symptoms on record | 41 signs |
| Status | published |
Treatment Summary
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO