Werner syndrome
MeSH: D014898ORPHA: 902
Overview
Lethal autosomal recessive disorder
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Werner syndrome, sourced from HPO and Orphanet clinical annotations.
HypogonadismConvex nasal ridgeCataractAbnormal thorax morphologyOsteoporosisSlender buildAbnormality of the voiceSparse scalp hairWhite forelockPremature graying of hairPili tortiShort staturePrematurely aged appearanceAbnormal hair whorlLipoatrophyAbnormal testis morphologyDecreased fertilityNarrow faceInsulin resistanceChondrocalcinosisHyperkeratosisCongestive heart failureMyocardial infarctionRocker bottom footAtherosclerosisSkeletal muscle atrophyPulmonary artery stenosisType II diabetes mellitusSubcutaneous calcificationAbnormal retinal pigmentationAplasia/Hypoplasia of the skinLipodystrophyAplasia/Hypoplasia of the testesIncreased bone mineral densityTelangiectasia of the skinLack of skin elasticitySkin ulcerSmall handHypertensionSecondary amenorrheaJoint stiffnessLaryngomalaciaNeoplasmGastrointestinal carcinomaMeningiomaSquamous cell carcinomaMelanomaThyroid carcinomaBreast carcinomaRenal neoplasmCutaneous melanomaAcral lentiginous melanomaSarcomaNeoplasm of the lungOvarian neoplasmNeoplasm of the oral cavityAbnormal cerebral vascular morphologyNeoplasm of the small intestine
Classification & Codes
MeSH Code
D014898Orphanet Code
ORPHA:902Werner syndrome
| MeSH | D014898 |
| Orphanet | ORPHA:902 |
| Treatments | 0 drug(s) |
| Symptoms on record | 58 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO