Wilson disease

MeSH: D006527ORPHA: 905

Overview

multisystem disease due to abnormal accumulation of copper

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with Wilson disease, sourced from HPO and Orphanet clinical annotations.

Gait disturbanceAmplification of sexual behaviorAbnormality of the menstrual cycleDepressionAggressive behaviorJaundiceBruising susceptibilityPruritusAbnormality of the handIntellectual disabilityDysarthriaArthritisJoint swellingCirrhosisHepatic steatosisFailure to thriveSplenomegalyWeight lossThrombocytopeniaAnemiaHepatomegalyClumsinessBone painPathologic fractureArthralgiaElevated circulating hepatic transaminase concentrationBack painIncreased body weightAcute hepatic failureProximal lower limb muscle weaknessHepatitisKayser-Fleischer ringAcute hepatitisPersonality changesOsteoporosisDystoniaTremorHemolytic anemiaChoreaDecreased circulating ceruloplasmin concentrationPsychosisHallucinationsAnxietyNephrolithiasisInfertilityHypoparathyroidismSeizureAscitesPancreatitisVomitingAbdominal painAminoaciduriaExcessive salivationFocal T2 hyperintense brainstem lesionInsomniaSunflower cataract

Classification & Codes

MeSH Code

D006527

Orphanet Code

ORPHA:905
Wilson disease
MeSHD006527
OrphanetORPHA:905
Treatments0 drug(s)
Symptoms on record56 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO