Wolman disease
MeSH: D015223ORPHA: 75233
Overview
autosomal recessive inborn error of metabolism that results in the body not producing enough active lysosomal acid lipase (LAL) enzyme
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Wolman disease, sourced from HPO and Orphanet clinical annotations.
Adrenal insufficiencyGlobal developmental delayHepatic failureGrowth delayAscitesSplenomegalyAnemiaFeverNausea and vomitingEsophageal varixHepatomegalySteatorrheaAbdominal distentionCachexiaBone-marrow foam cellsMalnutritionAdrenal calcification
Classification & Codes
MeSH Code
D015223Orphanet Code
ORPHA:75233Wolman disease
| MeSH | D015223 |
| Orphanet | ORPHA:75233 |
| Treatments | 0 drug(s) |
| Symptoms on record | 17 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO