Woodhouse–Sakati syndrome
MeSH: C536742ORPHA: 3464
Overview
Woodhouse-Sakati syndrome is a multisystemic disorder characterized by hypogonadism, alopecia, diabetes mellitus, intellectual deficit and extrapyramidal signs with choreoathetoid movements and dystonia
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Woodhouse–Sakati syndrome, sourced from HPO and Orphanet clinical annotations.
Hypoplasia of the uterusMicropenisHypogonadismProtruding earHypothyroidismDelayed pubertyDecreased response to growth hormone stimulation testInsulin-resistant diabetes mellitusHyperinsulinemiaOsteopeniaMild intellectual disabilityDysarthriaChoreoathetosisMental deteriorationDystoniaGrowth delayAlopeciaDelayed skeletal maturationHyperlipidemiaAbnormal T-wavePremature ovarian insufficiencyDecreased serum estradiolBilateral sensorineural hearing impairmentAbnormal spermatogenesisHypoplasia of the fallopian tubeDecreased testicular sizeStreak ovaryDecreased serum testosterone concentrationAplasia/Hypoplasia of the eyebrowTriangular faceProminent noseAnodontiaPsychosisHallucinationsScaling skin
Classification & Codes
MeSH Code
C536742Orphanet Code
ORPHA:3464Woodhouse–Sakati syndrome
| MeSH | C536742 |
| Orphanet | ORPHA:3464 |
| Treatments | 0 drug(s) |
| Symptoms on record | 35 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO