Worth's syndrome
ORPHA: 2790
Overview
hyperostosis that has material basis in a mutation in the LRP5 gene which results in increased bone density and bony structures located in palate
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Worth's syndrome, sourced from HPO and Orphanet clinical annotations.
Mandibular prognathiaSensorineural hearing impairmentNystagmusAbnormal rib morphologyAbnormal cortical bone morphologyAbnormal form of the vertebral bodiesCraniofacial hyperostosisDiaphyseal undertubulationGeneralized osteosclerosisFacial palsyTorus palatinusSclerotic vertebral bodyClavicular sclerosis
Classification & Codes
Orphanet Code
ORPHA:2790Worth's syndrome
| Orphanet | ORPHA:2790 |
| Treatments | 0 drug(s) |
| Symptoms on record | 13 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO