Xp22.13p22.2 duplication syndrome

ORPHA: 284180

Overview

human disease

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with Xp22.13p22.2 duplication syndrome, sourced from HPO and Orphanet clinical annotations.

MacroorchidismPolycystic ovariesHigh palateMicrocephalyMandibular prognathiaHypertelorismHearing impairmentFlared nostrilsBroad nasal tipShort neckStrabismusDownslanted palpebral fissuresHypermetropiaAnxietyPectus excavatumCongenital diaphragmatic herniaTapered fingerSeizureHypotoniaShort statureUmbilical herniaAbnormally high-pitched voiceTruncal obesityAbnormal facial shapeModerate intellectual disabilityScoliosisRecurrent upper respiratory tract infections2-3 toe syndactylyAttention deficit hyperactivity disorderSlowed slurred speechSparse hairHigh anterior hairlineModerate global developmental delaySmall hand

Classification & Codes

Orphanet Code

ORPHA:284180
Xp22.13p22.2 duplication syndrome
OrphanetORPHA:284180
Treatments0 drug(s)
Symptoms on record34 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO
Xp22.13p22.2 duplication syndrome | OrphanDrug