XYY syndrome

ICD-10: Q98.5MeSH: D014997ORPHA: 8

Overview

genetic condition in which a male has an extra Y chromosome

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with XYY syndrome, sourced from HPO and Orphanet clinical annotations.

TicsAbnormal emotional stateObsessive-compulsive traitReduced social responsivenessTall statureMalar flatteningLow-set earsDelayed speech and language developmentMotor delayMacrocephalyHypertelorismAtypical behaviorHyperactivityEnuresisIntellectual disabilityNeonatal hypotoniaSpecific learning disabilityTremorPes planusAsthmaAttention deficit hyperactivity disorderEarly-onset non-progressive night blindnessFinger clinodactylyImpulsivityAzoospermiaCryptorchidismHypospadiasMacroorchidismMicropenisHydrocephalusMandibular prognathiaAutistic behaviorAnxietyOligozoospermiaIncreased circulating gonadotropin levelSeizureMacrodontiaDysgenesis of the cerebellar vermisAbnormal brainstem morphologyMale infertilityCerebellar dysplasiaOppositional defiant disorderVaricoceleIncreased serum testosterone levelEncopresis

Classification & Codes

ICD-10 Code

Q98.5

MeSH Code

D014997

Orphanet Code

ORPHA:8
XYY syndrome
ICD-10Q98.5
MeSHD014997
OrphanetORPHA:8
Treatments0 drug(s)
Symptoms on record45 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO