XYYY syndrome

ORPHA: 99329

Overview

chromosomal disorder

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with XYYY syndrome, sourced from HPO and Orphanet clinical annotations.

Male hypogonadismAzoospermiaTall statureThick lower lip vermilionHigh palateEpicanthusHypertelorismLong philtrumShort neckAtypical behaviorAggressive behaviorLow frustration toleranceDelayed speech and language developmentGlobal developmental delayAbnormal renal morphologyAcneIntellectual disabilityMild intellectual disabilityAbnormal foot morphologyPes planusAsthmaRecurrent upper respiratory tract infectionsRadioulnar synostosisDislocated radial headDepressed nasal bridgeEnamel hypoplasiaIrregularly spaced teethAbnormal dermatoglyphicsPrimary gonadal insufficiencyFeeding difficultiesImpulsivity

Classification & Codes

Orphanet Code

ORPHA:99329
XYYY syndrome
OrphanetORPHA:99329
Treatments0 drug(s)
Symptoms on record31 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO