Yunis-Varon syndrome

MeSH: C536719ORPHA: 3472

Contents

1. Overview
2. Available Treatments
3. Clinical Presentation
4. Classification & Codes

Overview

Human disease

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with Yunis-Varon syndrome, sourced from HPO and Orphanet clinical annotations.

Aplasia of distal finger phalanxAplasia of the distal phalanx of the halluxShort proximal phalanx of halluxHypospadiasMicropenisShort upper lipBroad secondary alveolar ridgeThin vermilion borderDolichocephalyHypertelorismShort philtrumShort chinMicrognathiaHigh foreheadLow-set earsAbnormal pinna morphologyAnteverted naresCataractProptosisUpslanted palpebral fissureSclerocorneaSparse eyelashesSingle transverse palmar creaseSyndactylyAbnormal finger morphologyTapered fingerGlobal developmental delayAgenesis of corpus callosumPachygyriaSevere failure to thriveVentricular septal defectCardiomyopathyCardiomegalyShort toeRocker bottom footMetatarsus adductusPulmonary arterial hypertensionArrhinencephalySparse scalp hairNeuronal loss in central nervous systemAbnormal parietal bone morphologyHigh, narrow palateShort statureDecreased skull ossificationShortening of all distal phalanges of the toesShort middle phalanx of fingerRedundant neck skinPremature loss of primary teethAbsent sternal ossificationAplasia/Hypoplasia of the nipplesAplasia/Hypoplasia of the claviclesHypoplasia of the frontal lobesBilateral microphthalmosAplasia/Hypoplasia of the nailsPostnatal growth retardationGeneralized neonatal hypotoniaShort fingerAbsent thumbAplasia of the 1st metacarpalAplasia/hypoplasia of the 1st metatarsalWide cranial suturesAbnormality of dental structurePrimary microcephalyAbnormal occipital bone morphologyAbnormal pelvis bone morphologySparse eyebrowCryptorchidismHypoplastic labia majoraGlossoptosisHydrocephalusHearing impairmentMicrophthalmiaShort ribsHypertensionCerebellar hypoplasiaPolyhydramniosAtrial septal defectHydrops fetalisRenal artery stenosisPyloric stenosisHip dislocationFlared metaphysisSlender long bones with narrow diaphysesAplasia/Hypoplasia of the scapulaeClitoral hypertrophyIncreased nuchal translucencyNarrow nasal baseGingival recessionRenovascular hypertensionTetralogy of Fallot

Classification & Codes

MeSH Code

C536719

Orphanet Code

ORPHA:3472

Yunis-Varon syndrome

MeSH	`C536719`
Orphanet	`ORPHA:3472`
Treatments	0 drug(s)
Symptoms on record	90 signs
Status	published

Factual Authority

Last Updated3/20/2026

Clinical DataHPO · Orphanet

Drug DataFDA · EMA · CDSCO