familial reactive perforating collagenosis
MeSH: C565687ORPHA: 791472 Treatments Available
Overview
Familial reactive perforating collagenosis is a very rare genetic skin disease characterized by transepidermal elimination of collagen fibers presenting as recurrent spontaneously involuting keratotic papules or nodules
Available Treatments (2)
| Drug | Form | Status | Countries | Lead Time |
|---|---|---|---|---|
| Retinoids (Tretinoin) | Topical cream 0.025%, 0.05%, 0.1%; gel 0.01%, 0.025% | FDA Approved | 10 | 3d |
| Topical corticosteroids | Topical cream 0.05%, ointment 0.05%, solution 0.05% | FDA Approved | 10 | 2d |
Clinical Presentation
Signs and symptoms associated with familial reactive perforating collagenosis, sourced from HPO and Orphanet clinical annotations.
Erythematous papuleMaculopapular exanthemaSpotty hyperpigmentationInflammatory abnormality of the skinAbnormal epidermal morphologyIncreased number of elastic fibers in the dermisAbnormal cutaneous collagen fibril morphologyHyperkeratotic papuleAbnormal pinna morphologyAbnormality of the periorbital regionPruritusAbnormal scalp morphologyCrusting erythematous dermatitisPerifolliculitisAbnormal oral mucosa morphology
Classification & Codes
MeSH Code
C565687Orphanet Code
ORPHA:79147familial reactive perforating collagenosis
| MeSH | C565687 |
| Orphanet | ORPHA:79147 |
| Treatments | 2 drug(s) |
| Symptoms on record | 15 signs |
| Status | published |
Treatment Summary
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO